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TGF-1 evokes human airway smooth muscle cell shortening and hyperresponsiveness via Smad3

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Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123

By suppressing tyrosinase activity, hydroquinone slows melanin production